Optical autofocus for use with microtiter plates
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United States of America Patent
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Oct 10, 2000
Issued Date -
N/A
app pub date -
Feb 5, 1999
filing date -
Jan 7, 1999
priority date (Note) -
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status (Latency Note)
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Abstract
A method and apparatus for autofocus on a target layer contained within a microplate well is provided. The instrument is capable of optically sensing a reference point on the underside of a microplate. This reference point is then used to focus light onto a target layer within the microplate well, the target layer having a location that is in defined relation to the reference point. The reference point is either a surface of the bottom of the microplate well or is an optically detectable mark on the underside of the microplate. In an alternate embodiment, a light position sensitive detector is used to enable deterministic autofocus for a plurality of wells on a microplate.
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