Microencapsulated fluorinated gases for use as imaging agents
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United States of America Patent
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Oct 17, 2000
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N/A
app pub date -
Sep 22, 1998
filing date -
Mar 5, 1996
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Abstract
It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.
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