Stabilization of proteins in solution
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United States of America Patent
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Oct 17, 2000
Grant Date -
N/A
app pub date -
Jul 1, 1996
filing date -
Oct 8, 1993
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Abstract
A protein stabilizer additive comprises two or more of a tris compound of the formula (1): (HOCH.sub.2).sub.3 --C--R, wherein R is: C.sub.1 -C.sub.4 alkyl, substituted C.sub.1 -C.sub.4 alkyl, NH.sub.2 ; NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 may be independently: H, C.sub.1 -C.sub.4 alkyl sulphonate, C.sub.1 -C.sub.4 hydroxyalkyl sulphonate; C.sub.1 -C.sub.4 alkyl NHC(CH.sub.2 OH).sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 hydroxyalkyl; C.sub.1 -C.sub.4 alkyl carboxylate; a polyelectrolyte; a buffer; and one or more additional components for example divalent metal salts.
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