Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes
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United States of America Patent
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Oct 17, 2000
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N/A
app pub date -
Jun 5, 1995
filing date -
Oct 15, 1993
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Expired
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Abstract
A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise antisense oligonucleotides specific for nuclear proto-oncogenes. Preferably, antisense compounds of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.
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