Processes and intermediates for synthetic antibody derivatives

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United States of America Patent

PATENT NO 6136313
SERIAL NO

08403520

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention is directed to intermediates for use in the preparation of chimeric antibodies and synthetic antibody derivatives. The intermediates are open- or closed-hinge Fc fragments that have at least one alkylated external sulphydryl group. The invention is also directed to processes for making such intermediates, chimeric antibodies or synthetic antibody derivatives produced from the intermediates, and to methods of treating B-cell Lymphoma by administering chimeric antibodies or synthetic antibody derivatives produced using the intermediates of the invention.

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Patent Owner(s)

Patent OwnerAddress
3I RESEARCH EXPLOITATION LIMITEDLONDON SE1 8XP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Stevenson, George T Southampton, GB 2 65

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