Formulation for paclitaxel
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United States of America Patent
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-
Oct 24, 2000
Grant Date -
N/A
app pub date -
Oct 25, 1999
filing date -
Oct 25, 1999
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: water and micelles comprising paclitaxel and a pharmaceutically-acceptable, water-miscible solubilizer forming the micelles, the solubilizer selected from the group consisting of solubilizers having the general structures R.sub.1 COOR.sub.2, R.sub.1 CONR.sub.2, and R.sub.1 COR.sub.2, wherein R.sub.1 is a hydrophobic C.sub.3 -C.sub.50 alkane, alkene or alkyne and R.sub.2 is a hydrophilic moiety. The solubilizer is selected such that it does not have a pKa less than about 6.
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