Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
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United States of America Patent
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Oct 31, 2000
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N/A
app pub date -
Feb 18, 1998
filing date -
Feb 18, 1998
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Abstract
Endothelial cell attachment to an intravascular stent is promoted by coating the stent with an endothelial cell specific adhesion peptide. Coating is preferably carried out by activating the intravascular stent using plasma glow discharge, applying on the stent a layer or plurality of layers of a polymer such as poly(2-hydroxyethylmethacrylate), applying a tresylation solution containing pyridine and tresyl chloride, and applying a five amino acid peptide having the sequence glycine-arginine-glutamic acid-aspartic acid-valine.
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