Compositions for sorting polynucleotides
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Oct 31, 2000
Issued Date -
N/A
app pub date -
Oct 30, 1998
filing date -
Oct 13, 1994
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The invention provides a method and materials for sorting polynucleotides with oligonucleotide tags. Oligonucleotide tags of the invention are capable of hybridizing to complementary oligomeric compounds consisting of subunits having enhanced binding strength and specificity as compared to natural oligonucleotides. Such complementary oligomeric compounds are referred to herein as 'tag complements.' Subunits of tag complements may consist of monomers of non-natural nucleotide analogs, referred to herein as 'antisense monomers' or they may comprise oligomers having lengths in the range of 3 to 6 nucleotides or analogs thereof, including antisense monomers, the oligomers being selected from a minimally cross-hybridizing set. In such a set, a duplex made up of an oligomer of the set and the complement of any other oligomer of the set contains at least two mismatches. Preferred antisense monomers include peptide nucleic acid monomers and nucleoside phosphoramidates having a 3'-NHP(O)(O--)O-5' linkage with its adjacent nucleoside.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully