Device for incorporation and release of biologically active agents
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United States of America Patent
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Nov 7, 2000
Issued Date -
N/A
app pub date -
Jul 3, 1997
filing date -
May 10, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.
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