US Patent No: 6,143,948
Number of patents in Portfolio can not be more than 2000
Device for incorporation and release of biologically active agents
Stats
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Nov 7, 2000
Issued date -
Jul 3, 1997
filing date -
08/901,294
serial no -
Expired
status
Importance
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Abstract
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,847,163 Metal-metal oxide composites and a coating layer of calcium phosphate on the oxide layer | 23 | 1987 | |
| 4,911,953 Process for producing composite materials having a coating of calcium phosphate compound | 30 | 1988 | |
| 5,141,576 Titanium composite materials coated with calcium phosphate compound and process for production thereof | 27 | 1990 | |
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| 4,818,559 Method for producing endosseous implants | 114 | 1986 | |
| 5,030,474 Method for forming hydroxyapatite coating film using coating liquor containing hydroxyapatite | 38 | 1990 | |
| 5,128,169 Method for forming hydroxyapatite coating film | 32 | 1991 | |
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| 5,180,426 Composition for forming calcium phosphate type setting material and process for producing setting material | 65 | 1991 | |
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| 5,484,286 Method for the preparation of implants made of titanium or alloys thereof | 23 | 1993 | |
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| 5,603,338 Implant surface preparation utilizing acid treatment | 42 | 1996 | |
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| 5,947,893 Method of making a porous prothesis with biodegradable coatings | 88 | 1994 | |
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| 5,219,361 Soft tissue implant with micron-scale surface texture to optimize anchorage | 72 | 1992 | |
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| 5,071,436 Substitute bony matrix products promoting osteogenesis | 34 | 1991 | |
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| 4,879,136 Method of applying opaque dental ceramic material to a metal structure | 18 | 1987 | |
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| 4,538,306 Implantable elbow joint | 38 | 1983 | |
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| 4,687,487 Joint implant | 67 | 1985 | |
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| 4,746,532 Method for the production of endosseous implants | 32 | 1986 | |
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| 5,071,434 Biologically active surface ceramic and process for producing the same | 12 | 1991 | |
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| 5,478,237 Implant and method of making the same | 52 | 1993 | |
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| 4,880,610 In situ calcium phosphate minerals--method and composition | 139 | 1988 | |
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| 5,205,921 Method for depositing bioactive coatings on conductive substrates | 96 | 1991 | |
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| 5,358,529 Plastic knee femoral implants | 108 | 1993 | |
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| 5,456,723 Metallic implant anchorable to bone tissue for replacing a broken or diseased bone | 55 | 1992 | |
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| 4,636,526 Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics | 109 | 1985 | |
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| 5,344,457 Porous surfaced implant | 129 | 1993 | |
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| 4,846,837 Ceramic-coated metal implants | 35 | 1988 | |
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| 5,766,669 Sintering process for producing thin films of calcium phosphate entities | 46 | 1997 | |
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| 5,730,598 Prosthetic implants coated with hydroxylapatite and process for treating prosthetic implants plasma-sprayed with hydroxylapatite | 19 | 1997 | |
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| 4,863,474 Skeletal implants | 46 | 1988 | |
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| 4,330,891 Element for implantation in body tissue, particularly bone tissue | 118 | 1980 | |