In vitro-derived genetically altered human neutrophil precursor cells and methods for administering the same

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United States of America Patent

PATENT NO 6146623
SERIAL NO

08485579

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Abstract

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A composition comprising genetically altered human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% human myeloblasts and promyelocytes, which have been derived from neutrophil progenitor cells obtained from peripheral blood, bone marrow or cord blood, and less than about 5% colony forming units (CFU) of at least about 50 cells is provided. An alternative composition comprising genetically altered human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% CD15+CD11b- cells and less than about 5% colony forming units (CFU) of at least about 50 cells also is provided, wherein at least about 60% of the CD15+CD11b- cells are myeloblasts and promyelocytes.

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Patent Owner(s)

Patent OwnerAddress
NEXELL THERAPEUTICS INC9 PARKER IRVINE CA 92718

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bender, James G Lindenhurst, IL 18 505
Maples, Phillip B Waukegan, IL 22 161
Smith, Stephen Arlington Heights, IL 133 3148
Unverzagt, Kristen L Palatine, IL 5 36
Van, Epps Dennis E Cary, IL 50 963

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