Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
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United States of America Patent
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Nov 14, 2000
Issued Date -
N/A
app pub date -
Jul 8, 1998
filing date -
Sep 3, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to new amino acid derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR1## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
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