Red blood cells loaded with S-nitrosothiol and uses therefor

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6153186
SERIAL NO

08616255

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to .beta.93 cysteine residues, thereby shielding the NO functionality from heme inactivation. S-nitrosylation of Hb is under the allosteric control of oxygen and the oxidation state of heme. NO group release from SNO-Hb is further facilitated by intracellular low molecular weight thiols, forming RSNOs which can be exported from the erythrocyte to regulate blood pressure. Red blood cells can be loaded with low molecular weight RSNOs to act as a delivery system for NO.sup.+ groups. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O.sub.2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O.sub.2 delivery by red blood cells.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
DUKE UNIVERSITYDURHAM, NC795

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bonaventura, Joseph Durham, NC 35 512
Stamler, Jonathan S Chapel Hill, NC 120 1310

Cited Art Landscape

Patent Info (Count) # Cites Year
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (4)
* 5380758 S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof 113 1992
* 5427797 Systemic effects of nitric oxide inhalation 66 1993
* 5593876 Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality 42 1994
* 5574068 S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof 66 1994
 
THE OHIO STATE UNIVERSITY (1)
* 4900719 Nitrosothiols as hypotensive agents 26 1988
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
* 5480866 Hemoproteins for inhibition of nitric oxide-mediated hypotension and septic shock 25 1994
 
The United States of America as represented by the Department of Health and Human Services (1)
* 5405919 Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders 135 1992
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2003/0228,564 Nitric oxide in a pathogen inactivation process 20 2003
 
MONTANA STATE UNIVERSITY (2)
* 2003/0022,267 Method for determining physiological effects of hemoglobin 6 2002
* 2009/0232,909 Method for determining physiological effects of hemoglobin 0 2008
 
QUEEN'S UNIVERSITY AT KINGSTON (4)
6946484 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 10 2001
* 2005/0142,217 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 17 2001
8168232 Formulations and methods of using nitric oxide mimetics in cancer treatment 0 2010
* 2011/0028,543 Formulations and methods of using nitric oxide mimetics in cancer treatment 0 2010
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (2)
8647680 Methods and compositions for treatment of lesioned sites of body vessels 0 2010
* 2010/0233,263 METHODS AND COMPOSITIONS FOR TREATMENT OF LESIONED SITES OF BODY VESSELS 1 2010
 
DUKE UNIVERSITY (9)
6945247 Method of treating cardio pulmonary diseases with no group compounds 12 2000
* 6916471 Red blood cells loaded with S-nitrosothiol and uses therefor 1 2001
* 2006/0088,942 Measuring nitric oxide in blood gases and treatments based thereon 0 2003
7202340 No-modified hemoglobins and uses therefor 3 2003
* 2004/0132,638 No-modified hemoglobins and uses therefor 1 2003
* 2007/0191,478 Methods of treating cardio pulmonary diseases with NO group compounds 1 2005
7538193 NO-modified hemoglobins and uses therefor 0 2007
* 2007/0275,878 No-modified hemoglobins and uses therefor 0 2007
8871506 Methods for treating cardio pulmonary diseases with NO group compounds 0 2013
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
* 6872751 Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof 1 2002
* 2002/0164,383 Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof 0 2002
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (2)
7744928 Methods and compositions for treatment of lesioned sites of body vessels 0 2006
* 2007/0243,224 Methods and compositions for treatment of lesioned sites of body vessels 0 2006
 
WAKE FOREST UNIVERSITY HEALTH SCIENCES (2)
* 2007/0154,569 Use of nitrite salts for the treatment of cardiovascular conditions 27 2004
9387224 Treatment of specific cardiovascular conditions with nitrite 0 2012
 
Aires Pharmaceuticals, Inc. (1)
* 2009/0196,930 AEROSOLIZED NITRITE AND NITRIC OXIDE -DONATING COMPOUNDS AND USES THEREOF 20 2008
 
Menzies School of Health Research (1)
* 7179615 Method of prophylaxis and treatment 0 1998
 
CELLEGY PHARMACEUTICALS INC. (VAXIS) (2)
7678391 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 9 2003
* 2003/0215,528 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 22 2003
* Cited By Examiner