US Patent No: 6,153,186

Number of patents in Portfolio can not be more than 2000

Red blood cells loaded with S-nitrosothiol and uses therefor

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Abstract

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Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to .beta.93 cysteine residues, thereby shielding the NO functionality from heme inactivation. S-nitrosylation of Hb is under the allosteric control of oxygen and the oxidation state of heme. NO group release from SNO-Hb is further facilitated by intracellular low molecular weight thiols, forming RSNOs which can be exported from the erythrocyte to regulate blood pressure. Red blood cells can be loaded with low molecular weight RSNOs to act as a delivery system for NO.sup.+ groups. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O.sub.2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O.sub.2 delivery by red blood cells.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
DUKE UNIVERSITYDURHAM, NC736

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bonaventura, Joseph Durham, NC 35 481
Stamler, Jonathan S Chapel Hill, NC 120 1164

Cited Art Landscape

Patent Info (Count) # Cites Year
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (4)
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* 5,593,876 Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality 38 1994
* 5,574,068 S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof 63 1994
 
THE OHIO STATE UNIVERSITY (1)
* 4,900,719 Nitrosothiols as hypotensive agents 26 1988
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
* 5,480,866 Hemoproteins for inhibition of nitric oxide-mediated hypotension and septic shock 25 1994
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
* 5,405,919 Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders 125 1992
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
MONTANA STATE UNIVERSITY (2)
* 2003/0022,267 Method for determining physiological effects of hemoglobin 6 2002
* 2009/0232,909 Method for determining physiological effects of hemoglobin 0 2008
 
QUEEN'S UNIVERSITY AT KINGSTON (6)
6,946,484 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 7 2001
* 2005/0142,217 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 14 2001
7,678,391 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 6 2003
* 2003/0215,528 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 21 2003
8,168,232 Formulations and methods of using nitric oxide mimetics in cancer treatment 0 2010
* 2011/0028,543 Formulations and methods of using nitric oxide mimetics in cancer treatment 0 2010
 
Abbott Cardiovascular Systems Inc. (2)
8,647,680 Methods and compositions for treatment of lesioned sites of body vessels 0 2010
* 2010/0233,263 METHODS AND COMPOSITIONS FOR TREATMENT OF LESIONED SITES OF BODY VESSELS 1 2010
 
DUKE UNIVERSITY (9)
6,945,247 Method of treating cardio pulmonary diseases with no group compounds 12 2000
* 6,916,471 Red blood cells loaded with S-nitrosothiol and uses therefor 1 2001
* 2006/0088,942 Measuring nitric oxide in blood gases and treatments based thereon 0 2003
7,202,340 No-modified hemoglobins and uses therefor 3 2003
* 2004/0132,638 No-modified hemoglobins and uses therefor 1 2003
* 2007/0191,478 Methods of treating cardio pulmonary diseases with NO group compounds 1 2005
7,538,193 NO-modified hemoglobins and uses therefor 0 2007
* 2007/0275,878 No-modified hemoglobins and uses therefor 0 2007
8,871,506 Methods for treating cardio pulmonary diseases with NO group compounds 0 2013
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
* 6,872,751 Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof 0 2002
* 2002/0164,383 Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof 0 2002
 
Advanced Cardiovascular Systems, Inc. (2)
7,744,928 Methods and compositions for treatment of lesioned sites of body vessels 0 2006
* 2007/0243,224 Methods and compositions for treatment of lesioned sites of body vessels 0 2006
 
WAKE FOREST UNIVERSITY HEALTH SCIENCES (1)
9,387,224 Treatment of specific cardiovascular conditions with nitrite 0 2012
 
AIRES PHARMACEUTICALS, INC. (1)
* 2009/0196,930 AEROSOLIZED NITRITE AND NITRIC OXIDE -DONATING COMPOUNDS AND USES THEREOF 11 2008
 
Menzies School of Health Research (1)
* 7,179,615 Method of prophylaxis and treatment 0 1998
* Cited By Examiner