US Patent No: 6,153,186

Number of patents in Portfolio can not be more than 2000

Red blood cells loaded with S-nitrosothiol and uses therefor

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Abstract

Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to .beta.93 cysteine residues, thereby shielding the NO functionality from heme inactivation. S-nitrosylation of Hb is under the allosteric control of oxygen and the oxidation state of heme. NO group release from SNO-Hb is further facilitated by intracellular low molecular weight thiols, forming RSNOs which can be exported from the erythrocyte to regulate blood pressure. Red blood cells can be loaded with low molecular weight RSNOs to act as a delivery system for NO.sup.+ groups. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O.sub.2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O.sub.2 delivery by red blood cells.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
DUKE UNIVERSITYDURHAM, NC900

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bonaventura, Joseph Beaufort, NC 36 402
Stamler, Jonathan S Chapel Hill, NC 127 575

Cited Art

Patent Info (Count) # Cites Year
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (4)
5,380,758 S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof 98 1992
5,427,797 Systemic effects of nitric oxide inhalation 53 1993
5,593,876 Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality 33 1994
5,574,068 S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof 56 1994
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
5,480,866 Hemoproteins for inhibition of nitric oxide-mediated hypotension and septic shock 24 1994
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,405,919 Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders 101 1992
 
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (1)
4,900,719 Nitrosothiols as hypotensive agents 26 1988

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
DUKE UNIVERSITY (4)
6,945,247 Method of treating cardio pulmonary diseases with no group compounds 6 2000
6,916,471 Red blood cells loaded with S-nitrosothiol and uses therefor 0 2001
7,202,340 No-modified hemoglobins and uses therefor 0 2003
7,538,193 NO-modified hemoglobins and uses therefor 0 2007
 
QUEEN'S UNIVERSITY AT KINGSTON (3)
6,946,484 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 1 2001
7,678,391 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype 1 2003
8,168,232 Formulations and methods of using nitric oxide mimetics in cancer treatment 0 2010
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (1)
7,744,928 Methods and compositions for treatment of lesioned sites of body vessels 0 2006
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
6,872,751 Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof 0 2002
 
MENZIES SCHOOL OF HEALTH RESEARCH (1)
7,179,615 Method of prophylaxis and treatment 0 1998