Preparation with an acrylic-based, adhesive copolymeric matrix for the transdermal delivery of estradiol
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United States of America Patent
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-
Dec 5, 2000
Grant Date -
N/A
app pub date -
Jul 15, 1994
filing date -
Nov 25, 1991
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention is represented by a transdermal medicated patch for the extended release of 17.beta.-estradiol to the skin. The transdermal patch is formed by an outer covering, a matrix containing from 1% to 5% (w/w) 17.beta.-estradiol, and a protective liner which is removed before use. The matrix is formed of pressure-sensitive adhesive acrylic copolymers, in which the active ingredient is dissolved or dispersed. The acrylic copolymers are obtained by radical copolymerization of 2-ethylhexyl acrylate, methyl acrylate, acrylic acid, vinyl acetate, hydroxyethyl acrylate or a mixture thereof. Optionally quantities of less than 0.5% (w/w) of other substances may be added.
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