Serially directed combinatorial synthesis on fiber optic arrays
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United States of America Patent
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Dec 5, 2000
Grant Date -
N/A
app pub date -
Oct 28, 1997
filing date -
Oct 28, 1997
priority date (Note) -
Expired
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Abstract
A method has been developed which utilizes functionalized optical fibers as a solid support for the assembly of combinatorial libraries of compounds. The optical fibers are used to direct light, heat or a combination thereof to the compounds tethered to the fibers surface. Utilizing the method of the instant invention reactions occurring by both photochemically and thermally allowed pathways are accessible. In a preferred embodiment of the invention, the optical fibers are used to screen the array by fluorescence spectroscopy of labeled target molecules which bind to the immobilized library compounds.
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