Methods for using a phosphodiesterase in pharmaceutical screening to identify compounds for treatment of neoplasia
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United States of America Patent
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Dec 5, 2000
Issued Date -
N/A
app pub date -
Dec 19, 1998
filing date -
May 30, 1997
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Abstract
This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
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