Cross-linking tissue with a compound having a C.sub.8 to C.sub.40 aliphatic chain
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United States of America Patent
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Dec 5, 2000
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app pub date -
Jul 20, 1998
filing date -
Jul 20, 1998
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Abstract
Collagen-containing tissue is cross-linked to provide tissue suitable for use in production of bioprosthetic devices. A cross-linking agent is used having an aliphatic component containing about 8 to 40 carbon atoms and two collagen-reactive groups such as isocyanate, epoxy or n-hydroxysuccinimide. The cross-linking agent may be produced by dimerizing fatty acids, and modifying carboxylic acid group of the fatty acids before or after dimerization to contain collagen-reactive groups. The cross-linked tissue has desirable mechanical and biocompatibility features and a reduced susceptibility to calcification.
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