Modified release multiple-units dosage composition for release of opioid compounds
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United States of America Patent
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Dec 12, 2000
Grant Date -
N/A
app pub date -
Jun 22, 1998
filing date -
Mar 8, 1996
priority date (Note) -
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Abstract
An oral pharmaceutical modified release multiple-units composition for the administration of an analgesically effective amount of an opoid. The composition comprises at least two fractions wherein individual units containing an opoid are coated with a sustained release coating. A first fraction is adapted to relatively fast release while a second fraction is adapted to a delayed release. Such compositions make possible to obtain both a relatively fast onset of the analgesic effect and the maintenance of analgesically active plasma concentration for a relatively long period of time. The invention further relates to a process for the preparation of a composition according to the invention.
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