Method of treatment or inhibition of tumors using pyridyl-substituted metal-diphosphine complexes
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United States of America Patent
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Dec 12, 2000
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N/A
app pub date -
Aug 18, 1999
filing date -
Dec 9, 1994
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Abstract
A method of treatment or inhibition of tumors involves administering a compound to a subject. The compound is one in which one or more of the eight phenyl substituents in the compound [M(dppe).sub.2 ].sup.+, in which M is selected from Au(I), Ag(I) and Cu(I), is substituted by 2, 3, or 4 pyridyl substituents. The compound has anti-tumor activity and an octanol/water partition coefficient between 0.01 and 25.5. The compound has selective toxicity to cancer cells, including cisplatin resistant human carcinoma cells lines.
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