US Patent No: 6,162,467

Number of patents in Portfolio can not be more than 2000

Sustained release compositions and a method of preparing pharmaceutical compositions

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Importance

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Abstract

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A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EURO-CELTIQUE S.A.LUXEMBOURG162

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Challis, Deborah Kent, GB2 5 338
Heafield, Joanne Cambridge, GB2 11 589
Knott, Trevor John Wickford, GB2 12 530
Leslie, Stewart Thomas Cambridge, GB 23 935
Malkowska, Sandra Therese Antoinette Cambridge, GB 17 787
Miller, Ronald Brown Basel, CH 20 888
Prater, Derek Allan Cambridge, GB 31 947

Cited Art Landscape

Patent Info (Count) # Cites Year
 
PURDUE PHARMA L.P. (9)
4,828,836 Controlled release pharmaceutical composition 160 1987
4,834,985 Controlled release pharmaceutical composition 184 1987
4,990,341 Controlled release hydromorphone composition 108 1989
5,266,331 Controlled release oxycodone compositions 127 1991
5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 167 1991
5,286,493 Stabilized controlled release formulations having acrylic polymer coating 164 1992
5,549,912 Controlled release oxycodone compositions 119 1993
5,580,578 Controlled release formulations coated with aqueous dispersions of acrylic polymers 130 1993
5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 330 1995
 
EURO-CELTIQUE S.A. (5)
4,844,907 Pharmaceutical composition comprising analgesic and anti-inflammatory agent 118 1986
5,500,227 Immediate release tablet cores of insoluble drugs having sustained-release coating 124 1993
5,849,240 Method of preparing sustained release pharmaceutical compositions 92 1996
5,843,480 Controlled release diamorphine formulation 64 1996
5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions 92 1997
 
ALPHARMA PHARMACEUTICALS, LLC (2)
5,202,128 Sustained release pharmaceutical composition 135 1990
5,330,766 Sustained release pharmaceutical composition 92 1993
 
BASF AKTIENGESELLSCHAFT (2)
4,801,460 Preparation of solid pharmaceutical forms 120 1987
5,073,379 Continuous preparation of solid pharmaceutical forms 85 1989
 
GLATT GMBH (2)
4,967,486 Microwave assisted fluidized bed processor 33 1989
5,132,142 Apparatus and method for producing pellets by layering power onto particles 49 1991
 
PURDUE PHARMA COMPANY, THE (2)
4,861,598 Controlled release bases for pharmaceuticals 130 1986
4,970,075 Controlled release bases for pharmaceuticals 105 1989
 
SCHWARZ PHARMA AG (2)
5,453,283 Orally administered solvent-free pharmaceutical preparation with delayed active-substance release, and a method of preparing the preparation 21 1993
5,472,710 Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture 50 1994
 
Warner-Lambert Company (2)
4,483,847 Process for the manufacture of a pharmaceutical composition with a retarded liberation of active material 69 1983
5,167,964 Semi-enteric drug delivery systems and methods for preparing same 72 1992
 
YAMANOUCHI PHARMACEUTICAL CO., LTD. (2)
4,343,789 Sustained release pharmaceutical composition of solid medical material 79 1980
4,380,534 Solid drug preparations 41 1981
 
AKZO N.V. (1)
4,613,619 Anti-arrhythmic amino-alcohols 20 1985
 
ALFA WASSERMANN S.P.A. (1)
5,300,300 Controlled release gastroresistant pharmaceutical formulations for oral administration containing bile acids and their salts 30 1992
 
CADBURY ADAMS USA LLC (1)
4,894,234 Novel drug delivery system for antiarrhythmics 71 1988
 
CIBA SPECIALTY CHEMICALS CORPORATION (1)
4,310,483 Thermal tumbling granulation 36 1979
 
DepoMed Systems, Inc. (1)
5,007,790 Sustained-release oral drug dosage form 151 1989
 
DRUGTECH CORPORATION (1)
5,133,974 Extended release pharmaceutical formulations 244 1990
 
DUQUESNE UNIVERSITY OF THE HOLY GHOST, A CORP. OF PA. (1)
5,169,645 Directly compressible granules having improved flow properties 96 1989
 
ELAN PHARMA INTERNATIONAL LIMITED (1)
4,917,899 Controlled absorption diltiazem formulation 53 1987
 
Ethical Pharmaceuticals Limited (1)
4,880,830 Slow release formulation 47 1987
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (1)
4,844,909 Controlled release hydromorphone composition 102 1987
 
F.H. FAULDING & CO. LIMITED (1)
5,196,203 Theophylline dosage form 42 1991
 
FOREST LABORATORIES, INC. (1)
4,389,393 Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose 237 1982
 
GACELL LABORATORIES AB (1)
5,178,868 Dosage form 55 1991
 
Hoechst Aktiengesellschaft (1)
4,935,246 Process for the coating of granules 104 1988
 
INDRESCO, INC. (1)
4,329,794 Ripping attachment for dragline 31 1980
 
MERRELL DOW PHARMACEUTICALS INC. (1)
4,421,736 Sustained release diethylpropion compositions 58 1982
 
MITSUI CHEMICALS, INC. (1)
4,621,114 Propylene resin composition 34 1984
 
NAPP PHARMACEUTICAL GROUP LIMITED (1)
5,591,452 Controlled release formulation 77 1994
 
NIRO HOLDING A/S (1)
5,030,400 Process and an apparatus for agglomeration of a powdery material 62 1990
 
NOVARTIS AG (1)
5,403,593 Melt granulated compositions for preparing sustained release dosage forms 33 1992
 
Ortho Pharmaceutical Corporation (1)
5,395,626 Multilayered controlled release pharmaceutical dosage form 99 1994
 
PHARMACIA AB (1)
5,807,583 Process for the preparation of sustained release pellets 11 1995
 
PHARMASCIENCES, INC. (1)
4,925,675 Erythromycin microencapsulated granules 29 1988
 
PUREUE PHARMA L.P. (1)
4,834,984 Controlled release dihydrocodeine composition 97 1987
 
REVLON CONSUMER PRODUCTS CORPORATION (1)
5,271,934 Encapsulated antiperspirant salts and deodorant/antiperspirants 77 1992
 
SANKYO COMPANY, LIMITED (1)
4,533,562 Method of preparing coated solid preparations 51 1984
 
Sansho Co., Ltd. (1)
5,204,119 External preparation comprising calcium silicate 35 1991
 
SCHERING CORPORATION (1)
5,162,117 Controlled release flutamide composition 54 1991
 
SHIONOGI & CO., LTD. (1)
5,023,089 Sustained-release preparations and the process thereof 49 1989
 
SPRING AG, PHARMAZEUTISCHE PRAEPARATE A SWISS CORP. (1)
5,292,461 Process for the production of pellets 52 1991
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
5,443,846 Granulated preparations and method of producing the same 21 1994
 
TAKEDA PHARMACEUTICAL COMPANY LIMITED (1)
5,026,560 Spherical granules having core and their production 118 1988
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 105 1990
 
TEIJIN LIMITED (1)
4,801,458 Sustained release pharmaceutical plaster 92 1987
 
The Rockefeller University (1)
4,987,136 Method for controlling gastrointestinal dysmotility 106 1986
 
The Upjohn Company (1)
4,366,172 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use 30 1977
 
Other [Check patent profile for assignment information] (1)
4,259,314 Method and composition for the preparation of controlled long-acting pharmaceuticals 110 1979

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
PURDUE PHARMA L.P. (32)
6,696,088 Tamper-resistant oral opioid agonist formulations 87 2001
7,943,173 Pharmaceutical combinations of oxycodone and naloxone 2 2002
7,914,818 Opioid agonist formulations with releasable and sequestered antagonist 5 2002
6,696,066 Opioid agonist/antagonist combinations 79 2002
7,842,311 Tamper-resistant oral opioid agonist formulations 5 2003
7,172,767 Opioid agonist / antagonist combinations 42 2003
7,842,309 Tamper-resistant oral opioid agonist formulations 4 2003
7,718,192 Tamper-resistant oral opioid agonist formulations 12 2003
7,682,632 Tamper-resistant oral opioid agonist formulations 12 2003
7,658,939 Tamper-resistant oral opioid agonist formulations 14 2003
7,943,174 Controlled release hydrocodone formulations 8 2004
7,384,653 Oral dosage form comprising a therapeutic agent and an adverse-effect agent 16 2004
8,518,925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 0 2005
8,465,774 Sequestered antagonist formulations 0 2006
7,419,686 Opioid agonist/antagonist combinations 22 2006
7,749,542 Opioid agonist/antagonist combinations 7 2008
8,389,007 Pharmaceutical composition containing gelling agent 3 2008
8,105,631 Opioid agonist/antagonist combinations 6 2010
8,236,351 Tamper-resistant oral opioid agonist formulations 1 2010
8,231,901 Opioid agonist formulations with releasable and sequestered antagonist 0 2011
8,808,740 Encased tamper resistant controlled release dosage forms 0 2011
8,673,355 Opioid agonist/antagonist combinations 0 2011
8,846,090 Matrix for sustained, invariant and independent release of active compounds 0 2012
8,337,888 Pharmaceutical formulation containing gelling agent 11 2012
8,518,443 Opioid agonist formulations with releasable and sequestered antagonist 0 2012
8,357,399 Tamper-resistant oral opioid agonist formulations 1 2012
8,586,088 Tamper-resistant oral opioid agonist formulations 0 2012
8,758,825 Sequestered antagonist formulations 0 2013
8,609,683 Pharmaceutical formulation containing gelling agent 1 2013
8,529,948 Pharmaceutical formulation containing gelling agent 0 2013
8,815,287 Opiod agonist formulations with releasable and sequestered antagonist 0 2013
8,846,091 Matrix for sustained, invariant and independent release of active compounds 0 2013
 
ALPHARMA PHARMACEUTICALS, LLC (7)
8,158,156 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 0 2007
8,623,418 Pharmaceutical composition 0 2008
7,682,633 Pharmaceutical composition 7 2009
7,682,634 Pharmaceutical compositions 5 2009
8,685,443 Sequestering subunit and related compositions and methods 0 2010
8,685,444 Sequestering subunit and related compositions and methods 0 2010
8,846,104 Pharmaceutical compositions for the deterrence and/or prevention of abuse 0 2012
 
ABBVIE INC. (6)
8,377,952 Solid pharmaceutical dosage formulation 0 2005
8,333,990 Solid pharmaceutical dosage form 0 2010
8,309,613 Solid pharmaceutical dosage form 0 2010
8,399,015 Solid pharmaceutical dosage form 0 2011
8,268,349 Solid pharmaceutical dosage form 2 2012
8,691,878 Solid pharmaceutical dosage form 0 2012
 
COLLEGIUM PHARMACEUTICAL, INC. (6)
7,399,488 Abuse-deterrent pharmaceutical compositions of opiods and other drugs 18 2003
7,771,707 Abuse-deterrent drug formulations 5 2005
8,557,291 Abuse-deterrent pharmaceutical compositions of opioids and other drugs 1 2009
8,449,909 Abuse-deterrent drug formulations 3 2010
8,840,928 Tamper-resistant pharmaceutical compositions of opioids and other drugs 0 2010
8,758,813 Abuse-deterrent drug formulations 0 2013
 
ELITE LABORATORIES INC. (3)
8,182,836 Abuse-resistant oral dosage forms and method of use thereof 1 2009
8,425,933 Abuse-resistant oral dosage forms and method of use thereof 1 2009
8,703,186 Abuse-resistant oral dosage forms and method of use thereof 0 2013
 
LABOPHARM (BARBADOS) LIMITED - PARTIAL INTEREST (ENTIRE INTEREST OWNED BY LABOPHARM INC., LABOPHARM EUROPE LIMITED, AND LABOPHARM (BARBADOS) LIMITED) (3)
8,795,723 Sustained drug release compositions 0 2006
7,829,120 Trazodone composition for once a day administration 2 2006
8,414,919 Sustained drug release composition 1 2010
 
PALADIN LABS EUROPE LIMITED (2)
8,487,002 Controlled-release compositions 0 2005
7,988,998 Sustained-release tramadol formulations with 24-hour efficacy 2 2005
 
VALEANT INTERNATIONAL BERMUDA (2)
8,128,957 Modified release compositions of at least one form of tramadol 0 2004
8,158,147 Modified release formulations of at least one form of tramadol 0 2007
 
BASF AKTIENGESELLSCHAFT (1)
8,470,347 Self-emulsifying active substance formulation and use of this formulation 0 2001
 
CIMA LABS INC. (1)
8,445,018 Abuse resistant drug formulation 3 2008
 
CIRC PHARMA RESEARCH AND DEVELOPMENT LIMITED (1)
6,733,789 Multiparticulate bisoprolol formulation 5 2000
 
NAPP PHARMACEUTICAL GROUP LIMITED (1)
7,074,430 Controlled release tramadol tramadol formulation 18 2001
 
Other [Check patent profile for assignment information] (1)
8,410,129 Treatment for paresis/paralysis 0 2003