Modification of pertussis toxin
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United States of America Patent
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Jan 2, 2001
Grant Date -
N/A
app pub date -
May 21, 1998
filing date -
Aug 24, 1993
priority date (Note) -
Expired
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Abstract
The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
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