Oligonucleotide N3'.fwdarw.N5'Phosphoramidate Duplexes
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United States of America Patent
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Jan 2, 2001
Grant Date -
N/A
app pub date -
Sep 3, 1997
filing date -
Mar 18, 1994
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Abstract
Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more stable duplexes than phosphodiesters with complementary DNA and particularly RNA strands. Further, the phosphoramidate analogs can also form stable triplexes with double-stranded DNA target, where under similar conditions parent phosphodiester compounds failed to do so.
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