Processes for the synthesis of oligomeric compounds
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United States of America Patent
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Jan 2, 2001
Grant Date -
N/A
app pub date -
Nov 6, 1998
filing date -
Nov 6, 1998
priority date (Note) -
Expired
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Abstract
The present invention provides synthetic processes by which oligomeric compounds, having at least one phosphodiester or phosphorothioate linkage, are prepared. The synthetic processes use a novel mixture of concentrated ammonium hydroxide and a thiol compound during the deblocking step of all or selected internucleoside linkages. Alternatively, the deblocking is carried out in two steps using a mercapto compound in an aqueous amine followed by concentrated ammonium hydroxide. Also provided are synthetic intermediates useful in such processes. Novel oxidation procedures to give phosphodiester oligomers are also included.
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