Methods for determining cross-hybridization
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United States of America Patent
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Jan 9, 2001
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N/A
app pub date -
Jun 18, 1999
filing date -
Jul 13, 1998
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Abstract
The present invention provides methods for distinguishing the fractions of polynucleotide sequences which hybridize to any given probe, including probes on microarrays such as those described herein. In particular, the present invention enables users to identify the fraction of sequences which are perfectly complementary to a probe, thereby correcting for effects of cross hybridization in a hybridization assay. The methods of the invention work by monitoring the kinetics of dissociation of sequences from the probe so that a resulting 'dissociation curve' may be compared to a combination of the individual 'dissociation profiles' for each sequence which hybridizes. In alternative embodiments, the invention also provides computer systems for performing the present methods, as well as databases of the dissociation profiles.
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