Methods and compositions relating to no-mediated cytotoxicity
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United States of America Patent
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Jan 9, 2001
Grant Date -
N/A
app pub date -
Jul 30, 1998
filing date -
Jul 30, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic intervention of diabetes. The present invention demonstrates that MnSOD can play a protective role against cytokine killing, and provides strategies for engineering cell lines as islet surrogates for transplantation therapy of diabetes mellitus. Further, the present invention shows that .beta.-cell destruction and dysfunction in adipogenic diabetes is mediated via fatty acids. Methods and compositions for ameliorating this disorder are provided herein.
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