Amide compounds and use of the same
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United States of America Patent
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Jan 16, 2001
Grant Date -
N/A
app pub date -
Feb 20, 1998
filing date -
Aug 22, 1995
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
An amide compound of the formula (I): ##STR1## wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, hydroxy and the like, R.sup.5 is H, alkyl and the like, m is an integer of 0-6, R.sup.6 is an optionally substituted aryl and the like, and R.sup.7 is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-.alpha., GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.
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