Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine
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United States of America Patent
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Jan 16, 2001
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N/A
app pub date -
Sep 1, 1998
filing date -
Sep 1, 1998
priority date (Note) -
Expired
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Abstract
This invention presents novel processes for incorporating 2-aminoadenosine and 2-aminoadenosine analogs into oligonucleotides. A halogenated adeninosine is incorporated into an oligonucleotide using standard synthesis methods, such as phosphoramidited protocols. Subsequent reaction with an amine results in the desired product. The oligonucleotides produced provide stronger hybridization to their target sequences. These oligonucleotides can be useful compounds, inter alia for diagnostic and therapeutic applications.
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