Solid phase synthesis of thio-oligosaccharides
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United States of America Patent
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Jan 23, 2001
Grant Date -
N/A
app pub date -
Aug 7, 1998
filing date -
Aug 7, 1998
priority date (Note) -
Expired
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Abstract
Solid phase synthetic methods of forming sulfur-linked disaccharides and oligosaccharides are described, wherein a saccharide or oligosaccharide bearing a protected thiol-group at the anomeric carbon is immobilized onto a solid support at any position other than the anomeric carbon atom of the reducing sugar. The resultant immobilized thiol, or a derivative thereof, undergoes nuclcophilic saccharide addition to provide a di- or oligosaccharide.
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