Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction

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United States of America Patent

PATENT NO 6177555
SERIAL NO

09447863

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Abstract

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The presence of a target in a test mixture or the concentration of such target can be determined by a method relying on fluorescence emission measurement. Such method utilizes a nucleic acid ligand to the target and a ligand beacon comprising: i) a nucleic acid sequence complimentary to at least a portion of said nucleic acid ligand, ii) a fluorescent group, and iii) a fluorescence-modifying group. The emission profile of the ligand beacon is altered based on the presence and/or concentration change of the target in the test mixture.

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Patent Owner(s)

  • GILEAD SCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gold, Larry Boulder, CO 241 11500
Jayasena, Sumedha Boulder, CO 26 965

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