US Patent No: 6,183,434

Number of patents in Portfolio can not be more than 2000

Multiple mechanical microporation of skin or mucosa

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ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NITTO DENKO CORPORATIONOSAKA1966
SPECTRX, INC.TUCKER, GA38

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Eppstein, Jonathan A Atlanta, GA 41 3001

Cited Art

Patent Info (Count) # Cites Year
 
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ALZAK CORPORATION A CA. CORP (1)
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AMOCO CORPORATION (1)
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ENDODERMIC MEDICAL TECHNOLOGIES COMPANY (1)
5,421,816 Ultrasonic transdermal drug delivery system 103 1992
 
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (1)
5,250,023 Transdermal administration method of protein or peptide drug and its administration device thereof 171 1990
 
KUMETRIX, INC. (1)
5,801,057 Microsampling device and method of construction 266 1996
 
NEC CORPORATION (1)
5,882,317 Method and apparatus of sampling suction effusion fluid 9 1997
 
NITTO DENKO CORPORATION (1)
5,445,611 Enhancement of transdermal delivery with ultrasound and chemical enhancers 195 1993
 
NON-INVASIVE MONITORING COMPANY (NIMCO) (1)
5,458,140 Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers 245 1993
 
PESCADERO BEACH HOLDINGS CORPORATION (1)
5,169,389 Fluid delivery apparatus 44 1991
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (1)
5,223,219 Analytical cartridge and system for detecting analytes in liquid samples 104 1992
 
SIL MEDICS LTD. (1)
5,279,544 Transdermal or interdermal drug delivery devices 140 1992
 
SPECTRX, INC. (1)
6,022,316 Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications 116 1998
 
THE GENERAL HOSPITAL CORPORATION (1)
4,775,361 Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport 99 1986
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
5,115,805 Ultrasound-enhanced delivery of materials into and through the skin 73 1990

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
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7,077,840 Heads for dermatology treatment 18 2002
7,540,869 Method and apparatus for improved vascular related treatment 11 2002
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7,276,058 Method and apparatus for treatment of cutaneous and subcutaneous conditions 11 2003
7,135,033 Phototreatment device for use with coolants and topical substances 11 2003
6,974,451 Light energy delivery head 18 2003
7,309,335 Dermatological treatment with visualization 18 2004
7,220,254 Dermatological treatment with visualization 19 2004
7,431,719 System for electromagnetic radiation dermatology and head for use therewith 18 2005
7,763,016 Light energy delivery head 3 2005
7,758,621 Method and apparatus for therapeutic EMR treatment on the skin 2 2006
8,346,347 Skin optical characterization device 0 2006
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8,182,473 Cooling system for a photocosmetic device 0 2006
7,942,916 Phototreatment device for use with coolants and topical substances 3 2006
7,531,967 Flashlamp drive circuit 3 2007
8,328,794 System for electromagnetic radiation dermatology and head for use therewith 0 2008
7,935,107 Heads for dermatology treatment 4 2010
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8,109,924 Heads for dermatology treatment 0 2011
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BECTON, DICKINSON AND COMPANY (12)
6,835,184 Method and device for abrading skin 133 1999
6,595,947 Topical delivery of vaccines 17 2000
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CORIUM INTERNATIONAL, INC. (8)
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SYNERON MEDICAL LTD. (8)
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8,281,675 Dissolution rate verification 0 2008
8,337,493 Handheld transdermal drug delivery and analyte extraction 0 2011
 
INTUITY MEDICAL, INC. (7)
6,540,675 Analyte monitor 218 2000
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7,751,895 Tissue treatment device and method 0 2006
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8,419,719 Target-close electromagnetic energy emitting device 0 2010
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (6)
7,429,258 Microneedle transport device 7 2002
7,645,263 Impedance sensor 0 2002
7,364,568 Microneedle transdermal transport device 10 2002
7,066,922 Transdermal transport device with suction 12 2002
7,651,475 Microneedle transport device 5 2008
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VALERITAS, INC. (5)
7,530,968 Hydraulically actuated pump for long duration medicament administration 10 2004
7,914,499 Multi-cartridge fluid delivery device 5 2007
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8,070,726 Hydraulically actuated pump for long duration medicament administration 2 2008
8,361,053 Multi-cartridge fluid delivery device 0 2011
 
NITTO DENKO CORPORATION (4)
6,527,716 Microporation of tissue for delivery of bioactive agents 97 1999
8,016,811 Method for transdermal delivery of permeant substances 0 2003
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8,116,860 Transdermal porator and patch system and method for using same 0 2008
 
HISAMITSU PHARMACEUTICAL CO., INC. (2)
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SARNOFF (2)
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THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (2)
6,797,276 Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response 26 1999
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BACOUSTICS, LLC (1)
7,662,177 Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy 2 2006
 
STORZ ENDOSKOP PRODUKTIONS GMBH (1)
6,500,141 Apparatus and method for treating body tissue, in particular soft surface tissue with ultrasound 47 2000
 
THE GENERAL HOSPITAL CORPORATION (1)
8,268,332 Method for dermatological treatment using chromophores 0 2005
 
TOPPAN PRINTING CO., LTD. (1)
8,377,364 Method of manufacturing microneedle 0 2010
 
TRANSDERM TECHNOLOGIES LLC (1)
6,492,180 Non-invasive transdermal detection of analytes 29 1999
 
UNITED STATES OF AMERICA (1)
7,037,499 Adjuvant for transcutaneous immunization 7 1999
 
UNIVERSITY OF VIRGINIA (1)
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OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
7,896,819 Method of determining the concentration of an analyte in a body fluid and system in therefor 0 2005