US Patent No: 6,190,655

Number of patents in Portfolio can not be more than 2000

Methods of using Flt-3 ligand for exogenous gene transfer

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Abstract

Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancers.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CELLDEX THERAPEUTICS, INC.NEEDHAM, MA53

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beckmann, M Patricia Hansville, WA 43 505
Lyman, Stewart D Seattle, WA 35 125

Cited Art

Patent Info (Count) # Cites Year
 
PRINCETON UNIVERSITY (4)
5,283,354 Nucleic acids encoding hematopoietic stem cells receptors flk-1 56 1992
5,270,458 Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 51 1992
5,367,057 Tyrosine kinase receptor flk-2 and fragments thereof 22 1993
5,548,065 Tyrosine kinase receptor human flk-2-specific antibodies 18 1994
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (3)
5,399,493 Methods and compositions for the optimization of human hematopoietic progenitor cell cultures 45 1991
5,437,994 Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells 94 1993
5,459,069 Device for maintaining and growing human stem and/or hematopoietics cells 47 1994
 
Genentech, Inc. (1)
5,635,388 Agonist antibodies against the flk2/flt3 receptor and uses thereof 18 1994
 
GENETICS INSTITUTE, INC. (1)
5,326,558 Megakaryocytopoietic factor 39 1990
 
IMMUNEX CORPORATION (1)
5,199,942 Method for improving autologous transplantation 123 1991
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,399,346 Gene therapy 411 1994
 
NOVARTIS AG (1)
5,061,620 Human hematopoietic stem cell 218 1990
 
PHARMASTEM THERAPEUTICS, INC. (1)
5,192,553 Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use 137 1988
 
The Rockefeller University (1)
5,627,025 Method for the identification of compounds capable of abrogating human immunodeficiency virus (HIV) infection of dendritic cells and T-lymphocytes 16 1994
 
UCB FARCHIM SA (1)
5,525,708 Covalent dimer of kit ligand 10 1994
 
VANDERBILT UNIVERSITY (1)
5,453,357 Pluripotential embryonic stem cells and methods of making same 93 1992
 
Other [Check patent profile for assignment information] (1)
5,397,706 Serum-free basal and culture medium for hematopoietic and leukemia cells 18 1993

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Forward Cites

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LIFE TECHNOLOGIES CORPORATION (2)
7,541,184 Activation and expansion of cells 0 2004
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RIGEL PHARMACEUTICALS, INC. (1)
7,070,996 Production of cultured human mast cells and basophils for high throughput small molecule drug discovery 11 2001
 
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (1)
8,216,585 Targeted particles and methods of using the same 0 2002