Human therapeutic uses of BPI protein products
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United States of America Patent
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Feb 20, 2001
Grant Date -
N/A
app pub date -
Sep 2, 1999
filing date -
Jan 24, 1994
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Abstract
Disclosed are methods for treatment of humans exposed to bacterial endotoxin in circulation by administration of bactericidal/permeability-increasing (BPI) protein products. Serologically and hematologically verifiable alleviation of endotoxin mediated increases in circulating cytokines, fibrinolysis and coagulation factors and changes in lymphocyte counts are observed upon such treatment. Also observed is alleviation of endotoxin mediated decreases in systemic vascular resistance index (SVRI) and concomitant increases in cardiac index (CI).
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