Calcification-resistant biomaterials
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United States of America Patent
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Feb 27, 2001
Grant Date -
N/A
app pub date -
Sep 17, 1997
filing date -
Feb 5, 1996
priority date (Note) -
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Abstract
In general, the invention features a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structure having a quantity of calcification inhibitors releasably bound thereto. The storage structure can be a protein or a synthetic polymer. The calcification inhibitors include metal ions and phosphatase inhibitors generally. Bifunctional metal chelators can be bound to endogenous proteins to deliver metal ions.
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