Compositions comprising complement receptor type 1 molecules having carbohydrate structures that are selectin ligands
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United States of America Patent
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Feb 27, 2001
Issued Date -
N/A
app pub date -
May 25, 1995
filing date -
May 17, 1993
priority date (Note) -
Expired
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Abstract
The present invention provides compositions comprising at least one complement moiety and at least one carbohydrate moiety, and methods of producing such compositions. In particular, the compositions of the invention comprise complement proteins related to the complement receptor type 1, and further comprise ligands for intercellular molecules, such as selectins. In a preferred embodiment, the compositions comprise a complement-related protein in combination with the Lewis X antigen or the sialyl Lewis X antigen. The compositions of the invention have use in the diagnosis or therapy of disorders involving complement activity and inflammation. Pharmaceutical compositions are also provided for treating or reducing inflammation mediated by inappropriate complement activity and intercellular adhesion.
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