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Abstract

A method for detecting a target nucleic acid molecule hybridized with a nucleic acid probe, comprising the steps of: (a) hybridizing a target nucleic acid molecule having a specific sequence to be detected in a sample with a nucleic acid probe having a sequence complementary to the sequence of the nucleic acid molecule, the nucleic acid probe being selected such that the nucleic acid molecule and the probe are partially hybridized to represent a linear conformation in a hybridized region and to represent, in an non-hybridized region, a unique structure inherent to its nucleotide sequence; (b) measuring the conformation, structure and length of the nucleic acid molecule obtained in step (a); and (c) on the basis of the measurement data obtained in the step (b), detecting the nucleic acid containing both of the linear conformation and the unique structure, thereby detecting the nucleic acid molecule hybridized with the probe.

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First Claim