Peptide production as fusion protein in transgenic mammal milk
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United States of America Patent
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Mar 6, 2001
Grant Date -
N/A
app pub date -
Sep 25, 1997
filing date -
Apr 8, 1994
priority date (Note) -
Expired
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Abstract
Peptides can be produced in and purified from the milk of transgenic animals. The peptides are made as fusion proteins with a suitable fusion partner such as .alpha.-lactalbumin, which is a natural milk protein. The fusion partner protein acts to promote secretion of the peptides and, at least in the case of .alpha.-lactalbumin, allows a single-step purification based on specific affinity. The peptide is released from the purified fusion protein by a simple cleavage step and purified away from the now liberated .alpha.-lactalbumin by repeating the same affinity purification method. A particular advantage of producing peptides via this route, in addition to the obvious advantages of high yield and biocompatibility, is that specific post-translational modifications, such as carboxy terminal amidation, can be performed in the mammary gland.
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