Composition for enhanced uptake of polar drugs from the colon
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United States of America Patent
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Mar 13, 2001
Grant Date -
N/A
app pub date -
Mar 30, 1998
filing date -
Aug 8, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a drug delivery composition for colonic delivery comprising a polar drug, an absorption promoter which (a) comprises a mixture of a fatty acid having 6 to 16 carbon atoms or a salt thereof and a dispersing agent, or (b) comprises a mixture of mono/diglycerides of medium chain fatty acids and a dispersing agent, and means adapted to release the polar drug and absorption promoter in the colon following oral administration. A preferred fatty acid is capric acid or a salt thereof. Colon specific delivery can be achieved by providing the composition in a capsule, tablet or pellet which is coated with a material which dissolves in the small intestine or is degraded by the conditions in the colon.
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