Diaminorhodamine derivatives

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United States of America Patent

PATENT NO 6201134
SERIAL NO

09446899

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A compound represented by the following general formula: ##STR1## wherein R.sup.1 and R.sup.2 represent amino groups present at adjacent positions each other on the phenyl ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently represent a C.sub.1-6 alkyl group; R.sup.7, R.sup.8, R.sup.9 and R.sup.10 independently represent a hydrogen atom, a C.sub.1-6 alkyl group, an allyl group, or a halogen atom; R.sup.11 represents a hydrogen atom or a C.sub.1-18 alkyl group; and X.sup.- represents an anion, and an agent for nitric oxide measurement comprising said compound. The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.

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Patent Owner(s)

Patent OwnerAddress
NAGANO TETSUOTOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kojima, Hirotatsu Tokyo, JP 31 145
Nagano, Tetsuo Tokyo, JP 89 406

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