Low-toxicity human interferon-alpha analogs
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United States of America Patent
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Mar 20, 2001
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N/A
app pub date -
Oct 20, 1997
filing date -
Apr 12, 1996
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Expired
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Abstract
The invention describes a method of reducing the cytotoxicity of interferon-alpha by making defined amino acid substitutions in the N-terminal portion of the polypeptide sequence. Also described are human interferon-alpha analogs with low cytotoxicity, and therapeutic applications of the low toxicity interferon-alpha analogs.
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