Antisense inhibition of Fas mediated signaling

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United States of America Patent

PATENT NO 6204055
SERIAL NO

09290640

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.

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Patent Owner(s)

Patent OwnerAddress
ISIS PHARMACEUTICALS INC2280 FARADAY AVENUE CARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dean, Nicholas M Olivenhain, CA 126 2851
Marcusson, Eric G San Diego, CA 63 1332

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