Coumarin-based CYP3A fluorescent assay reagents
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United States of America Patent
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Mar 27, 2001
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N/A
app pub date -
Sep 30, 1999
filing date -
Sep 30, 1999
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Abstract
Novel fluorescent substrates of human cytochrome P450 enzymes are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing cytochrome P450 enzyme activity and in selecting compounds which inhibit cytochrome P450 enzyme activity and, in particular, for identifying potential adverse drug interactions which are mediated by inhibition of cytochrome P450 enzyme activity. The compounds are particularly useful for assessing cytochrome P450 CYP3A enzyme activity.
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