Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
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United States of America Patent
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Mar 27, 2001
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N/A
app pub date -
Feb 12, 1999
filing date -
Feb 12, 1999
priority date (Note) -
Expired
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Abstract
Synthetic processes are provided wherein mixed backbone oligomeric compounds are prepared having at least one phosphodiester intemucleoside linkage in addition to one or more phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Novel H-phosphonate intermediates are also disclosed that are useful in the synthetic processes. The synthetic processes use a novel oxidation step to oxidize H-phosphonate internuleoside linkages to phosphodiester internuleoside linkages without degradation of adjacent phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Also provided are synthetic intermediates useful in such processes.
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