Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography

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United States of America Patent

PATENT NO 6208415
SERIAL NO

09096434

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Abstract

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Employing a low coherence Michelson interferometer, two dimensional images of optical birefringence in turbid samples as a function of depth are measured. Polarization sensitive detection of the signal formed by interference of backscattered light from the sample and a mirror or reference plane in the reference arm which defines a reference optical path length, give the optical phase delay between light propagating along the fast and slow axes of the birefringence sample. Images showing the change in birefringence in response to irradiation of the sample are produced as an example of the detection apparatus and methodology. The technique allow rapid, noncontact investigation of tissue or sample diagnostic imaging for various medical or materials procedures.

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REGENTS OF THE UNIVERSITY OF CALIFORNIA THE1111 FRANKLIN STREET 12TH FLOOR OAKLAND CA 94607

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Boer Johannes F Irvine, CA 34 2936
Milner, Thomas E Austin, TX 91 4736
Nelson, J Stuart Laguna Niguel, CA 19 2330

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