Non-linear optical tomography of turbid media

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United States of America Patent

PATENT NO 6208886
SERIAL NO

09054743

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Abstract

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An apparatus utilizing non-linear optical signals for use in constructing a three-dimensional tomographic map of an in vivo biological tissue for medical disease detection purposes. In one embodiment, said apparatus comprises a stage for supporting the in vivo biological tissue; a laser for illuminating the in vivo biological tissue with a focused beam of laser light, the light emerging from the in vivo biological tissue comprising fundamental light, harmonic wave light, and fluorescence due to multi-photon excitation; a filter for selectively passing only at least one of the harmonic wave light and the fluorescence; one or more detectors for individually detecting each of the harmonic wave light and the fluorescence selectively passed; and a mechanism for moving the laser relative to the stage in x, y and z directions.

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Patent Owner(s)

Patent OwnerAddress
ALFANO OPTICAL TOMOGRAPHY LLC75 MONTEBELLO ROAD SUFFERN NY 10901

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alfano, Robert R Bronx, NY 141 7099
Guo, Yici Jackson Height, NY 3 106
Ho, Ping Pei Great Neck, NY 4 780
Liu, Feng Bronx, NY 583 7601

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