Method for gene transfer to the central nervous system
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United States of America Patent
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Apr 3, 2001
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N/A
app pub date -
Apr 8, 1996
filing date -
Apr 8, 1996
priority date (Note) -
Expired
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Abstract
The present invention relates to a method for implanting producer cells into the mammalian brain. The producer cells are engineered with a retroviral based recombinant vector encoding a tumorcidal factor or susceptibility factor that confers on tumor cells sensitivity to chemotherapeutic or radiotherapeutic agents. Prior to transplantation into the mammalian brain, the producer cells are first cultured in vitro on a support matrix to increase the long-term viability of the transplanted cells and to provide long-term functional benefit.
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