Analytical methods and apparatus employing an optical sensor device with refractive index modulation
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United States of America Patent
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Apr 17, 2001
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N/A
app pub date -
Oct 12, 1999
filing date -
Feb 8, 1996
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Abstract
A method for monitoring the interaction of molecular species utilizes a sensor device comprising a substrate (1) with a waveguide (2) formed on the surface thereof. A grating (3) is formed in one of the surfaces of the waveguide (2). A beam of light (6) is incident on the grating (3) and the angle of incidence at which maximum reflection occurs is monitored. A first molecular species is immobilized on the waveguide (2). Changes in the angular position of the reflection maximum provide an indication of interaction of the first molecular species with a second molecular species contained in a sample brought into contact with the sensor device.
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