Amyloid .beta. protein (globular assembly and uses thereof)

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United States of America Patent

PATENT NO 6218506
SERIAL NO

08796089

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention described in this disclosure involves a new composition of matter, amyloid beta-derived dementing ligands (ADDL's). ADDLs consist of amyloid .beta. peptide assembled into soluble globular non-fibrillar oligomeric structures that are capable of activating specific cellular processes. The invention further encompasses methods for assaying the formation, presence, receptor protein binding and cellular activities of ADDLs. The invention further encompasses assay methods and inhibitor molecules for cellular signaling molecules activated by ADDLs. Also described are molecules that block proteins that promote the formation of ADDLs.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NORTHWESTERN UNIVERSITYEVANSTON, IL995
UNIVERSITY OF SOUTHERN CALIFORNIALOS ANGELES, CA905

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barlow, Ann Evanston, IL 3 142
Chromy, Brett A Evanston, IL 14 252
Finch, Caleb E Altadena, CA 5 225
Klein, William L Winnetka, IL 29 488
Krafft, Grant A Glenview, IL 26 373
Lambert, Mary P Glenview, IL 21 384
Morgan, Todd Manhattan Beach, CA 9 160
Rozovsky, Irina Pasadena, CA 3 142
Wals, Pat Los Angeles, CA 3 142

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
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NORTHWESTERN UNIVERSITY (8)
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Northwestern University & the University of Southern California (1)
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BIOARCTIC NEUROSCIENCE AB (9)
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REGENTS OF THE UNIVERSITY OF MINNESOTA (1)
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UNIVERSITY OF WASHINGTON (4)
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* Cited By Examiner