Surface cross-linked particles suitable for controlled delivery
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United States of America Patent
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Apr 24, 2001
Grant Date -
N/A
app pub date -
Aug 28, 1998
filing date -
Aug 29, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Cross-linked particles are provided that are useful for delivery of pharmaceutical agents. The particles comprise at least one polymeric compound and a spacer compound, where the polymeric compound and the spacer each comprise reactive carboxyl, hydrazidyl, amino and/or thiol groups. The particles are cross-linked via covalent linkage of the reactive groups on the polymer and spacer respectively. Compositions comprising pharmaceutical agents contained within the particles are disclosed. Methods for preparing the particles, for encapsulating pharmaceutical agents within the particles, and for using the particles for controlled release of the pharmaceutical agent within the patient also are provided.
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