Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
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United States of America Patent
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Apr 24, 2001
Grant Date -
N/A
app pub date -
Jan 26, 1999
filing date -
Jan 6, 1993
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
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