Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion
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United States of America Patent
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May 8, 2001
Grant Date -
N/A
app pub date -
Sep 9, 1998
filing date -
Feb 12, 1998
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Abstract
The present invention discloses techniques for controlling abnormal involuntary movement (AIM) disorders as experienced by persons with Parkinson's disease under high dosage of levodopa by electrical stimulation and/or drug infusion. The present invention utilizes an implantable signal generator and an electrode and/or an implantable pump and catheter. High electrical stimulation pulses and/or drug therapy is provided to predetermined portions of the brain to blocking neural activity in the Centremedian-Parafasicularis nucleus thereby reducing activity in the medial pallidal nucleus (GPi) which, in turn, reduces the AIM disorder. A sensor may be used to detect the symptoms resulting from the AIM disorder. A microprocessor or algorithm may then analyzes the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.
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