Device for tissue engineering bone
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United States of America Patent
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-
May 8, 2001
Grant Date -
N/A
app pub date -
Jul 15, 1998
filing date -
Jul 16, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolyester and cultured osteogenic or osteoprogenitor cells, especially bone cells. The copolyester consists essentially of a multiplicity of recurring long-chain ester units and short-chain ester units, the long-chain ester units comprising from 35 to 80% by weight of the copolyester and being represented by the formula --OLO--CO-- or --OLO--CO--R--CO-- and the short-chain ester units being represented by the formula --OEO--CO--R--CO-- and/or --O--Q--CO-- wherein L is a divalent group remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol with an average molecular weight of between 300 and 3000; R is a divalent group remaining after removal of carboxyl groups from a dicarboxylic acid having a molecular weight of less than 300; Q is an alkylene group having 1-6 carbon atoms and/or a cyclohexylene of phenylene group; and E is an alkylene group having 2-6 carbon atoms.
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